P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis.
Sobia ManzoorMadiha KhalidMuhammad IdreesPublished in: PloS one (2022)
In conclusion, these findings constitute the evidence that P2X4 receptors in the presence of HCV play a significant role in the regulation of key antioxidant enzymes (HO-1, Cu/ZnSOD), in the induction of proinflammatory. cytokine (TNF-α), profibrotic cytokine (TGF-β) vasoactive cytokine (angiotensin II). P2X4 also increases the expression of extracellular matrix proteins (laminin and elastin) in the presence of HCV.
Keyphrases
- extracellular matrix
- angiotensin ii
- hepatitis c virus
- angiotensin converting enzyme
- human immunodeficiency virus
- vascular smooth muscle cells
- poor prognosis
- rheumatoid arthritis
- oxidative stress
- transforming growth factor
- binding protein
- long non coding rna
- metal organic framework
- hiv infected
- cell proliferation
- liver fibrosis