KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis.

Tanja LimbergerMichaela SchledererKarolina TrachtováInes Garces de Los Fayos AlonsoJiaye YangSandra HöglerChristina SternbergVojtech BystryJan OppeltBoris TichýMargit SchmeidlPetra KodajovaAnton JägerHeidi A NeubauerMonika OberhuberBelinda S SchmalzbauerSarka PospisilovaHelmut DolznigWolfgang WadsakZoran CuligSuzanne D TurnerGerda EggerSabine LaggerLukas Kenner

Published in: Molecular cancer (2022)

We identified truncating events of KMT2C as drivers of proliferation and PIN formation. Loss of PTEN and KMT2C in prostate cancer results in loss of senescence, metastatic dissemination and reduced life expectancy. Our data demonstrate the prognostic significance of KMT2C mutation status in prostate cancer patients. Inhibition of the MYC signalling axis may be a viable treatment option for patients with KMT2C truncations and therefore poor prognosis.

Keyphrases

poor prognosis
prostate cancer
long non coding rna
radical prostatectomy
signaling pathway
squamous cell carcinoma
transcription factor
small cell lung cancer
cell proliferation
dna damage
endothelial cells
electronic health record
pi k akt
binding protein
benign prostatic hyperplasia
data analysis