IL-12 and IL-15 induce the expression of CXCR6 and CD49a on peripheral natural killer cells.
Theresa J HydesAngela NollGabriela Salinas-RiesterMohammed AbuhilalThomas ArmstrongZaed HamadyJohn PrimroseArjun TakharLutz WalterSalim I KhakooPublished in: Immunity, inflammation and disease (2017)
IL-12 and IL-15 may be key for generating NK cells with a tissue-homing phenotype and strong Th1 cytokine profile in the blood, and links peripheral activation of NK cells with tissue-homing. These findings may have important therapeutic implications for immunotherapy of chronic liver disease.