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HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity.

Priyanka S RanaJames J Ignatz-HooverByung-Gyu KimEhsan MalekYuriy FedorovDrew J AdamsTimothy A ChanJames J Driscoll
Published in: Cancer research communications (2024)
The elimination of therapy-resistant tumor cells remains a major challenge in the treatment of multiple myeloma. Our study identifies and functionally validates agents that amplify MHC class I-presented antigens and pave the way for the development of proteasome activators as immune adjuvants to enhance immunotherapeutic responses in patients with multiple myeloma.
Keyphrases
  • multiple myeloma
  • genome wide
  • dendritic cells
  • stem cells
  • histone deacetylase
  • dna methylation
  • mesenchymal stem cells
  • cell therapy