Timothy A Chan (Timothy Chan)

ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 54

Top Venues

Nature communications

Nature genetics

Cancer research communications

Science immunology

Memorial Sloan-Kettering Cancer Center

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Memorial Sloan-Kettering Cancer Center Aug 01 2007

United States

Member/Professor :: Human Oncology and Pathogenesis Program

Publications

Priyanka S Rana, James J Ignatz-Hoover, Byung-Gyu Kim, Ehsan Malek, Yuriy Fedorov, Drew J Adams, Timothy A Chan, James J Driscoll
HDAC6 inhibition releases HR23B to activate proteasomes, expand the tumor immunopeptidome and amplify T-cell antimyeloma activity. Cancer research communications (2024)
Hieu Minh Ta, Dia Roy, Keman Zhang, Tyler J Alban, Ivan Juric, Juan Dong, Prerana Bangalore Parthasarathy, Sachin Patnaik, Elizabeth Delaney, Cassandra Gilmour, Amin Zakeri, Nidhi Shukla, Amit Rupani, Yee Peng Phoon, Caini Liu, Stefanie Avril, Brian R Gastman, Timothy A Chan, Li Lily Wang
LRIG1 engages ligand VISTA and impairs tumor-specific CD8 + T cell responses. Science immunology 9 (95) (2024)
Hieu Minh Ta, Dia Roy, Keman Zhang, Tyler J Alban, Ivan Juric, Juan Dong, Prerana Bangalore Parthasarathy, Sachin Patnaik, Elizabeth Delaney, Cassandra Gilmour, Amin Zakeri, Nidhi Shukla, Amit Rupani, Yee Peng Phoon, Caini Liu, Stefanie Avril, Brian R Gastman, Timothy A Chan, Li Lily Wang
LRIG1 engages ligand VISTA and impairs tumor-specific CD8 + T cell responses. Science immunology 9 (95) (2024)
Priyanka S Rana, James J Ignatz-Hoover, Byung-Gyu Kim, Ehsan Malek, Yuriy Fedorov, Drew J Adams, Timothy A Chan, James J Driscoll
HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity. Cancer research communications 4 (6) (2024)
Hieu Minh Ta, Dia Roy, Keman Zhang, Tyler J Alban, Ivan Juric, Juan Dong, Prerana Bangalore Parthasarathy, Sachin Patnaik, Elizabeth Delaney, Cassandra Gilmour, Amin Zakeri, Nidhi Shukla, Amit Rupani, Yee Peng Phoon, Caini Liu, Stefanie Avril, Brian R Gastman, Timothy A Chan, Li Lily Wang
LRIG1 engages ligand VISTA and impairs tumor-specific CD8 + T cell responses. Science immunology 9 (95) (2024)
Priyanka S Rana, James J Ignatz-Hoover, Byung-Gyu Kim, Ehsan Malek, Yuriy Fedorov, Drew J Adams, Timothy A Chan, James J Driscoll
HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity. Cancer research communications 4 (6) (2024)
Hieu Minh Ta, Dia Roy, Keman Zhang, Tyler J Alban, Ivan Juric, Juan Dong, Prerana Bangalore Parthasarathy, Sachin Patnaik, Elizabeth Delaney, Cassandra Gilmour, Amin Zakeri, Nidhi Shukla, Amit Rupani, Yee Peng Phoon, Caini Liu, Stefanie Avril, Brian R Gastman, Timothy A Chan, Li Lily Wang
LRIG1 engages ligand VISTA and impairs tumor-specific CD8 + T cell responses. Science immunology 9 (95) (2024)
Hieu Minh Ta, Dia Roy, Keman Zhang, Tyler J Alban, Ivan Juric, Juan Dong, Prerana Bangalore Parthasarathy, Sachin Patnaik, Elizabeth Delaney, Cassandra Gilmour, Amin Zakeri, Nidhi Shukla, Amit Rupani, Yee Peng Phoon, Caini Liu, Stefanie Avril, Brian R Gastman, Timothy A Chan, Li Lily Wang
LRIG1 engages ligand VISTA and impairs tumor-specific CD8 + T cell responses. Science immunology 9 (95) (2024)
Priyanka S Rana, James J Ignatz-Hoover, Byung-Gyu Kim, Ehsan Malek, Yuriy Fedorov, Drew J Adams, Timothy A Chan, James J Driscoll
HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity. Cancer research communications 4 (6) (2024)
Priyanka S Rana, James J Ignatz-Hoover, Byung-Gyu Kim, Ehsan Malek, Yuriy Fedorov, Drew J Adams, Timothy A Chan, James J Driscoll
HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity. Cancer research communications 4 (6) (2024)
Hieu Minh Ta, Dia Roy, Keman Zhang, Tyler J Alban, Ivan Juric, Juan Dong, Prerana Bangalore Parthasarathy, Sachin Patnaik, Elizabeth Delaney, Cassandra Gilmour, Amin Zakeri, Nidhi Shukla, Amit Rupani, Yee Peng Phoon, Caini Liu, Stefanie Avril, Brian R Gastman, Timothy A Chan, Li Lily Wang
LRIG1 engages ligand VISTA and impairs tumor-specific CD8 + T cell responses. Science immunology 9 (95) (2024)
Priyanka S Rana, James J Ignatz-Hoover, Byung-Gyu Kim, Ehsan Malek, Yuriy Fedorov, Drew J Adams, Timothy A Chan, James J Driscoll
HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity. Cancer research communications 4 (6) (2024)
Luis Zapata, Giulio Caravagna, Marc J Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore Milite, Ahmet Acar, Nadeem Riaz, Timothy A Chan, Trevor A Graham, Andrea Sottoriva
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors. Nature genetics (2023)
Hong Qiu, Vladimir Makarov, Jennifer K Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V Iyer, Hannah C Johnsen, Daniel Kim, Varna Thayaparan, Daniel J Lindner, Georges-Pascal Haber, Angela H Ting, Bing Ren, Timothy A Chan, Vivek K Arora, David B Solit, Byron H Lee
KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Cancer research 83 (6) (2023)
Joris L Vos, Bharat Burman, Swati Jain, Conall W R Fitzgerald, Eric J Sherman, Lara A Dunn, James V Fetten, Loren S Michel, Anuja Kriplani, Kenneth K Ng, Juliana Eng, Vatche Tchekmedyian, Sofia Haque, Nora Katabi, Fengshen Kuo, Catherine Y Han, Zaineb Nadeem, Wei Yang, Vladimir Makarov, Raghvendra M Srivastava, Irina Ostrovnaya, Manu Prasad, Charlotte L Zuur, Nadeem Riaz, David G Pfister, Christopher A Klebanoff, Timothy A Chan, Alan L Ho, Luc G T Morris
Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial. Nature medicine (2023)
Avia D Wilkerson, Prerana Bangalore Parthasarathy, Nickolas Stabellini, Carley Mitchell, Paul G Pavicic, Pingfu Fu, Amit Rupani, Hana Husic, Patricia A Rayman, Shadi Swaidani, Jame Abraham, George T Budd, Halle C F Moore, Zahraa Al-Hilli, Jennifer Susan Ko, Joseph Baar, Timothy A Chan, Tyler J Alban, C Marcela Diaz-Montero, Alberto J Montero
Phase II Clinical Trial of Pembrolizumab and Chemotherapy Reveals Distinct Transcriptomic Profiles by Radiologic Response in Metastatic Triple-Negative Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Luis Zapata, Giulio Caravagna, Marc J Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore Milite, Ahmet Acar, Nadeem Riaz, Timothy A Chan, Trevor A Graham, Andrea Sottoriva
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors. Nature genetics 55 (3) (2023)
Luis Zapata, Giulio Caravagna, Marc J Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore Milite, Ahmet Acar, Nadeem Riaz, Timothy A Chan, Trevor A Graham, Andrea Sottoriva
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors. Nature genetics 55 (3) (2023)
Hong Qiu, Vladimir Makarov, Jennifer K Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V Iyer, Hannah C Johnsen, Daniel Kim, Varna Thayaparan, Daniel J Lindner, Georges-Pascal Haber, Angela H Ting, Bing Ren, Timothy A Chan, Vivek K Arora, David B Solit, Byron H Lee
KDM6A loss triggers an epigenetic switch that disrupts urothelial differentiation and drives cell proliferation in bladder cancer. Cancer research (2023)
Alan Shen, Michelle Arbesman, Roshan Lodha, Patricia A Rayman, Brandon Bungo, Ying Ni, Timothy A Chan, Brian R Gastman, Jennifer Susan Ko, C Marcela Diaz-Montero, Joshua Arbesman, Pauline Funchain
Clinical and Immunologic Features of Germline Pathogenic Variant (gPV) Positive Patients with Melanoma. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Ian Ganly, Fengshen Kuo, Vladimir Makarov, Yiyu Dong, Ronald A Ghossein, Ronald A Ghossein, Luc G T Morris, Timothy A Chan
Characterizing the Immune Microenvironment and Neoantigen Landscape of Hürthle Cell Carcinoma to Identify Potential Immunologic Vulnerabilities. Cancer research communications 3 (7) (2023)
Hong Qiu, Vladimir Makarov, Jennifer K Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V Iyer, Hannah C Johnsen, Daniel Kim, Varna Thayaparan, Daniel J Lindner, Georges-Pascal Haber, Angela H Ting, Bing Ren, Timothy A Chan, Vivek K Arora, David B Solit, Byron H Lee
KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Cancer research 83 (6) (2023)
Luis Zapata, Giulio Caravagna, Marc J Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore Milite, Ahmet Acar, Nadeem Riaz, Timothy A Chan, Trevor A Graham, Andrea Sottoriva
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors. Nature genetics 55 (3) (2023)
Hong Qiu, Vladimir Makarov, Jennifer K Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V Iyer, Hannah C Johnsen, Daniel Kim, Varna Thayaparan, Daniel J Lindner, Georges-Pascal Haber, Angela H Ting, Bing Ren, Timothy A Chan, Vivek K Arora, David B Solit, Byron H Lee
KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Cancer research 83 (6) (2023)
Hong Qiu, Vladimir Makarov, Jennifer K Bolzenius, Angela Halstead, Yvonne Parker, Allen Wang, Gopakumar V Iyer, Hannah C Johnsen, Daniel Kim, Varna Thayaparan, Daniel J Lindner, Georges-Pascal Haber, Angela H Ting, Bing Ren, Timothy A Chan, Vivek K Arora, David B Solit, Byron H Lee
KDM6A Loss Triggers an Epigenetic Switch That Disrupts Urothelial Differentiation and Drives Cell Proliferation in Bladder Cancer. Cancer research 83 (6) (2023)
Kailin Yang, Ahmed Halima, Timothy A Chan
Antigen presentation in cancer - mechanisms and clinical implications for immunotherapy. Nature reviews. Clinical oncology (2023)
Luis Zapata, Giulio Caravagna, Marc J Williams, Eszter Lakatos, Khalid AbdulJabbar, Benjamin Werner, Diego Chowell, Chela James, Lucie Gourmet, Salvatore Milite, Ahmet Acar, Nadeem Riaz, Timothy A Chan, Trevor A Graham, Andrea Sottoriva
Immune selection determines tumor antigenicity and influences response to checkpoint inhibitors. Nature genetics 55 (3) (2023)
Joshua I Warrick, Wenhuo Hu, Hironobu Yamashita, Vonn Walter, Lauren Shuman, Jenna M Craig, Lan L Gellert, Mauro A A Castro, A Gordon Robertson, Fengshen Kuo, Irina Ostrovnaya, Judy Sarungbam, Ying-Bei Chen, Anuradha Gopalan, Sahussapont J Sirintrapun, Samson W Fine, Satish K Tickoo, Kwanghee Kim, Jasmine Thomas, Nagar Karan, Sizhi Paul Gao, Timothy N Clinton, Andrew T Lenis, Timothy A Chan, Zhiyu Chen, Manisha Rao, Travis J Hollman, Yanyun Li, Nicholas D Socci, Shweta Chavan, Agnes Viale, Neeman Mohibullah, Bernard H Bochner, Eugene J Pietzak, Min Yuen Teo, Gopakumar V Iyer, Jonathan E Rosenberg, Dean F Bajorin, Matthew Kaag, Suzanne B Merrill, Monika Joshi, Rosalyn M Adam, John A Taylor, Peter E Clark, Jay D Raman, Victor E Reuter, Juliet Chen, Samuel A Funt, David B Solit, David J DeGraff, Hikmat A Al-Ahmadie
Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation. Nature communications 13 (1) (2022)
Phillip M Rappold, Lynda Vuong, Josef Leibold, Nicholas H Chakiryan, Michael Curry, Fengshen Kuo, Erich Sabio, Hui Jiang, Briana G Nixon, Ming Liu, Anders E Berglund, Andrew W Silagy, Eduardo A Mascareno, Mahdi Golkaram, Mahtab Marker, Albert Reising, Alexander Savchenko, John M Millholland, Ying-Bei Chen, Paul Russo, Jonathan A Coleman, Ed Reznik, Brandon J Manley, Irina Ostrovnaya, Vladimir Makarov, Renzo G DiNatale, Kyle A Blum, Xiaoxiao Ma, Diego Chowell, Ming O Li, David B Solit, Scott W Lowe, Timothy A Chan, Robert J Motzer, Martin H Voss, Abraham Ari Hakimi
A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma. Cancer discovery 12 (10) (2022)
Mathieu Gigoux, Morten Orebo Holmström, Roberta Zappasodi, Joseph J Park, Stephane Pourpe, Cansu Cimen Bozkus, Levi Mark Mangarin, David Redmond, Svena Verma, Sara Schad, Mariam M George, Divya Venkatesh, Arnab Ghosh, David Hoyos, Zaki Molvi, Baransel Kamaz, Anna E Marneth, William Duke, Matthew Joseph Leventhal, Max Jan, Vincent T Ho, Gabriela S Hobbs, Trine Alma Knudsen, Vibe Skov, Lasse Kjær, Thomas Stauffer Larsen, Dennis Lund Hansen, R Coleman Lindsley, Hans Carl Carl Hasselbalch, Jacob H Grauslund, Thomas L Lisle, Özcan Met, Patrick Wilkinson, Benjamin Greenbaum, Manuel A Sepulveda, Timothy A Chan, Raajit Rampal, Mads Hald Andersen, Omar Abdel-Wahab, Nina Bhardwaj, Jedd D Wolchok, Ann Mullally, Taha Merghoub
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine. Science translational medicine 14 (649) (2022)
Xiaoxiao Ma, Nadeem Riaz, Robert M Samstein, Mark Lee, Vladimir Makarov, Cristina Valero, Diego Chowell, Fengshen Kuo, Douglas Hoen, Conall W R Fitzgerald, Hui Jiang, Jonathan Alektiar, Tyler J Alban, Ivan Juric, Prerana Bangalore Parthasarathy, Yu Zhao, Erich Y Sabio, Richa Verma, Raghvendra M Srivastava, Lynda Vuong, Wei Yang, Xiao Zhang, Jingming Wang, Lawrence K Chu, Stephen L Wang, Daniel W Kelly, Isaac X Pei, Jiapeng Chen, Rona Yaeger, Dmitriy Zamarin, Ahmet Zehir, Mithat Gönen, Luc G T Morris, Timothy A Chan
Functional landscapes of POLE and POLD1 mutations in checkpoint blockade-dependent antitumor immunity. Nature genetics 54 (7) (2022)
Carla Danussi, Promita Bose, Prasanna T Parthasarathy, Pedro C Silberman, John S Van Arnam, Mark Vitucci, Oliver Y Tang, Adriana Heguy, Yuxiang Wang, Timothy A Chan, Gregory J Riggins, Erik P Sulman, Frederick F Lang, Chad J Creighton, Benjamin Deneen, C Ryan Miller, David J Picketts, Kasthuri Kannan, Jason T Huse
Author Correction: Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nature communications 13 (1) (2022)
Joshua I Warrick, Wenhuo Hu, Hironobu Yamashita, Vonn Walter, Lauren Shuman, Jenna M Craig, Lan L Gellert, Mauro A A Castro, A Gordon Robertson, Fengshen Kuo, Irina Ostrovnaya, Judy Sarungbam, Ying-Bei Chen, Anuradha Gopalan, Sahussapont J Sirintrapun, Samson W Fine, Satish K Tickoo, Kwanghee Kim, Jasmine Thomas, Nagar Karan, Sizhi Paul Gao, Timothy N Clinton, Andrew T Lenis, Timothy A Chan, Zhiyu Chen, Manisha Rao, Travis J Hollman, Yanyun Li, Nicholas D Socci, Shweta Chavan, Agnes Viale, Neeman Mohibullah, Bernard H Bochner, Eugene J Pietzak, Min Yuen Teo, Gopakumar V Iyer, Jonathan E Rosenberg, Dean F Bajorin, Matthew Kaag, Suzanne B Merrill, Monika Joshi, Rosalyn M Adam, John A Taylor, Peter E Clark, Jay D Raman, Victor E Reuter, Juliet Chen, Samuel A Funt, David B Solit, David J DeGraff, Hikmat A Al-Ahmadie
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation. Nature communications 13 (1) (2022)
Ian Ganly, Eric Minwei Liu, Fengshen Kuo, Vladimir Makarov, Yiyu Dong, Jinsung Park, Yongxing Gong, Alexander N Gorelick, Jeffrey A Knauf, Elisa Benedetti, Jacqueline Tait-Mulder, Luc G T Morris, James A Fagin, Andrew M Intlekofer, Jan Krumsiek, Payam A Gammage, Ronald Ghossein, Ronald A Ghossein, Timothy A Chan, Ed Reznik
Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma. Science advances 8 (25) (2022)
Joshua I Warrick, Wenhuo Hu, Hironobu Yamashita, Vonn Walter, Lauren Shuman, Jenna M Craig, Lan L Gellert, Mauro A A Castro, A Gordon Robertson, Fengshen Kuo, Irina Ostrovnaya, Judy Sarungbam, Ying-Bei Chen, Anuradha Gopalan, Sahussapont J Sirintrapun, Samson W Fine, Satish K Tickoo, Kwanghee Kim, Jasmine Thomas, Nagar Karan, Sizhi Paul Gao, Timothy N Clinton, Andrew T Lenis, Timothy A Chan, Zhiyu Chen, Manisha Rao, Travis J Hollman, Yanyun Li, Nicholas D Socci, Shweta Chavan, Agnes Viale, Neeman Mohibullah, Bernard H Bochner, Eugene J Pietzak, Min Yuen Teo, Gopakumar V Iyer, Jonathan E Rosenberg, Dean F Bajorin, Matthew Kaag, Suzanne B Merrill, Monika Joshi, Rosalyn M Adam, John A Taylor, Peter E Clark, Jay D Raman, Victor E Reuter, Juliet Chen, Samuel A Funt, David B Solit, David J DeGraff, Hikmat A Al-Ahmadie
Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation. Nature communications 13 (1) (2022)
Joshua I Warrick, Wenhuo Hu, Hironobu Yamashita, Vonn Walter, Lauren Shuman, Jenna M Craig, Lan L Gellert, Mauro A A Castro, A Gordon Robertson, Fengshen Kuo, Irina Ostrovnaya, Judy Sarungbam, Ying-Bei Chen, Anuradha Gopalan, Sahussapont J Sirintrapun, Samson W Fine, Satish K Tickoo, Kwanghee Kim, Jasmine Thomas, Nagar Karan, Sizhi Paul Gao, Timothy N Clinton, Andrew T Lenis, Timothy A Chan, Zhiyu Chen, Manisha Rao, Travis J Hollman, Yanyun Li, Nicholas D Socci, Shweta Chavan, Agnes Viale, Neeman Mohibullah, Bernard H Bochner, Eugene J Pietzak, Min Yuen Teo, Gopakumar V Iyer, Jonathan E Rosenberg, Dean F Bajorin, Matthew Kaag, Suzanne B Merrill, Monika Joshi, Rosalyn M Adam, John A Taylor, Peter E Clark, Jay D Raman, Victor E Reuter, Juliet Chen, Samuel A Funt, David B Solit, David J DeGraff, Hikmat A Al-Ahmadie
Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation. Nature communications 13 (1) (2022)
Olusegun Isaac Alatise, Gregory C Knapp, Avinash Sharma, Walid K Chatila, Olukayode A Arowolo, Olalekan Olasehinde, Olusola C Famurewa, Adeleye D Omisore, Akinwumi O Komolafe, Olaejirinde Olaniyi Olaofe, Aba I Katung, David E Ibikunle, Adedeji A Egberongbe, Samuel A Olatoke, Sulaiman O Agodirin, Olusola A Adesiyun, Ademola Adeyeye, Oladapo A Kolawole, Akinwumi O Olakanmi, Kanika Arora, Jeremy Constable, Ronak Shah, Azfar Basunia, Brooke Sylvester, Chao Wu, Martin R Weiser, Ken Seier, Mithat Gonen, Zsofia K Stadler, Yelena M Kemel, Efsevia Vakiani, Michael F Berger, Timothy A Chan, David B Solit, Jinru Shia, Francisco Sanchez-Vega, Nikolaus Schultz, Murray F Brennan, J Joshua Smith, Thomas Peter Kingham
Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights. Nature communications 12 (1) (2021)
Diego Chowell, Seong-Keun Yoo, Cristina Valero, Alessandro Pastore, Chirag Krishna, Mark Lee, Douglas Hoen, Hongyu Shi, Daniel W Kelly, Neal Patel, Vladimir Makarov, Xiaoxiao Ma, Lynda Vuong, Erich Y Sabio, Kate Weiss, Fengshen Kuo, Tobias L Lenz, Robert M Samstein, Nadeem Riaz, Prasad S Adusumilli, Vinod P Balachandran, George Plitas, A Ari Hakimi, Omar Abdel-Wahab, Alexander N Shoushtari, Michael A Postow, Robert J Motzer, Marc Ladanyi, Ahmet Zehir, Michael F Berger, Mithat Gönen, Luc G T Morris, Nils Weinhold, Timothy A Chan
Improved prediction of immune checkpoint blockade efficacy across multiple cancer types. Nature biotechnology (2021)
Abraham Ari Hakimi, Kyrollis Attalla, Renzo G DiNatale, Irina Ostrovnaya, Jessica Flynn, Kyle A Blum, Yasser Ged, Douglas Hoen, Sviatoslav M Kendall, Ed Reznik, Anita Bowman, Jason Hwee, Christopher J Fong, Fengshen Kuo, Martin H Voss, Timothy A Chan, Robert J Motzer
A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response. Nature communications 11 (1) (2020)
Ming O Li, Fengshen Kuo, Kristelle J Capistrano, Davina Kang, Briana G Nixon, Wei Shi, Chun Chou, Mytrang H Do, Efstathios G Stamatiades, Shengyu Gao, Shun Li, Ying-Bei Chen, James J Hsieh, Abraham Ari Hakimi, Ichiro Taniuchi, Timothy A Chan, Ming O Li
TGF-β suppresses type 2 immunity to cancer. Nature 587 (7832) (2020)
Simon Heidegger, Alexander Wintges, Florian Stritzke, Sarah Bek, Katja Steiger, Paul-Albert Koenig, Sascha Göttert, Thomas Engleitner, Rupert Öllinger, Tatiana Nedelko, Julius Clemens Fischer, Vladimir Makarov, Christof Winter, Roland Rad, Marcel R M van den Brink, Juergen Ruland, Florian Bassermann, Timothy A Chan, Tobias Haas, Hendrik Poeck
RIG-I activation is critical for responsiveness to checkpoint blockade. Science immunology 4 (39) (2020)
Yuxiang Wang, Aaron T Wild, Sevin Turcan, Wei H Wu, Carlie Sigel, David S Klimstra, Xiaoxiao Ma, Yongxing Gong, Eric C Holland, Jason T Huse, Timothy A Chan
Targeting therapeutic vulnerabilities with PARP inhibition and radiation in IDH-mutant gliomas and cholangiocarcinomas. Science advances 6 (17) (2020)
Rouven Hoefflin, Sabine Harlander, Silvia Schäfer, Patrick Metzger, Fengshen Kuo, Désirée Schönenberger, Mojca Adlesic, Asin Peighambari, Philipp Seidel, Chia-Yi Chen, Miguel Consenza-Contreras, Andreas Jud, Bernd Lahrmann, Niels Grabe, Danijela Heide, Franziska Maria Uhl, Timothy A Chan, Justus Duyster, Robert Zeiser, Christoph Schell, Mathias Heikenwalder, Oliver Schilling, Abraham Ari Hakimi, Melanie Boerries, Ian J Frew
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice. Nature communications 11 (1) (2020)
Lorenzo Galluzzi, Timothy A Chan, Guido Kroemer, Jedd D Wolchok, Alejandro López-Soto
The hallmarks of successful anticancer immunotherapy. Science translational medicine 10 (459) (2019)
Jonathan J Havel, Diego Chowell, Timothy A Chan
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy. Nature reviews. Cancer 19 (3) (2019)
Wei Yang, Ken-Wing Lee, Raghvendra M Srivastava, Fengshen Kuo, Chirag Krishna, Diego Chowell, Vladimir Makarov, Douglas Hoen, Martin G Dalin, Leonard Wexler, Ronald Ghossein, Nora Katabi, Zaineb Nadeem, Marc A Cohen, S Ken Tian, Nicolas Robine, Kanika Arora, Heather Geiger, Phaedra Agius, Nancy Bouvier, Kety Huberman, Katelynd Vanness, Jonathan J Havel, Jennifer S Sims, Robert M Samstein, Rajarsi Mandal, Justin Tepe, Ian Ganly, Alan L Ho, Nadeem Riaz, Richard J Wong, Neerav Shukla, Timothy A Chan, Luc G T Morris
Immunogenic neoantigens derived from gene fusions stimulate T cell responses. Nature medicine 25 (5) (2019)
Yuxiang Wang, Jie Yang, Aaron T Wild, Wei H Wu, Rachna Shah, Carla Danussi, Gregory J Riggins, Kasthuri Kannan, Erik P Sulman, Timothy A Chan, Jason T Huse
G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma. Nature communications 10 (1) (2019)
Rajarsi Mandal, Robert M Samstein, Ken-Wing Lee, Jonathan J Havel, Hao Wang, Chirag Krishna, Erich Y Sabio, Vladimir Makarov, Fengshen Kuo, Pedro Blecua, Apoorva T Ramaswamy, Jennifer N Durham, Bjarne Bartlett, Xiaoxiao Ma, Raghvendra Srivastava, Sumit Middha, Ahmet Zehir, Jaclyn F Hechtman, Luc G T Morris, Nils Weinhold, Nadeem Riaz, Dung T Le, Luis A Diaz, Timothy A Chan
Genetic diversity of tumors with mismatch repair deficiency influences anti-PD-1 immunotherapy response. Science (New York, N.Y.) 364 (6439) (2019)
Diego Chowell, Chirag Krishna, Federica Pierini, Vladimir Makarov, Naiyer A Rizvi, Fengshen Kuo, Luc G T Morris, Nadeem Riaz, Tobias L Lenz, Timothy A Chan
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy. Nature medicine 25 (11) (2019)
Robert M Samstein, Chung-Han Lee, Alexander N Shoushtari, Matthew D Hellmann, Ronglai Shen, Yelena Y Janjigian, David A Barron, Ahmet Zehir, Emmet J Jordan, Antonio Omuro, Thomas J Kaley, Sviatoslav M Kendall, Robert J Motzer, A Ari Hakimi, Martin H Voss, Paul Russo, Jonathan Rosenberg, Gopakumar V Iyer, Bernard H Bochner, Dean F Bajorin, Hikmat A Al-Ahmadie, Jamie E Chaft, Charles M Rudin, Gregory J Riely, Shrujal Baxi, Alan L Ho, Richard J Wong, David G Pfister, Jedd D Wolchok, Christopher A Barker, Philip H Gutin, Cameron W Brennan, Viviane Tabar, Ingo K Mellinghoff, Lisa M DeAngelis, Charlotte E Ariyan, Nancy Lee, William D Tap, Mrinal M Gounder, Sandra P D'Angelo, Leonard Saltz, Zsofia K Stadler, Howard I Scher, Jose Baselga, Pedram Razavi, Christopher A Klebanoff, Rona Yaeger, Neil H Segal, Geoffrey Y Ku, Ronald P DeMatteo, Marc Ladanyi, Naiyer A Rizvi, Michael F Berger, Nadeem Riaz, David B Solit, Timothy A Chan, Luc G T Morris
Tumor mutational load predicts survival after immunotherapy across multiple cancer types. Nature genetics 51 (2) (2019)
Carla Danussi, Promita Bose, Prasanna T Parthasarathy, Pedro C Silberman, John S Van Arnam, Mark Vitucci, Oliver Y Tang, Adriana Heguy, Yuxiang Wang, Timothy A Chan, Gregory J Riggins, Erik P Sulman, Frederick Lang, Chad J Creighton, Benjamin Deneen, C Ryan Miller, David J Picketts, Kasthuri Kannan, Jason T Huse
Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling. Nature communications 9 (1) (2018)
Chang S Chan, Saurabh V Laddha, Peter W Lewis, Matthew S Koletsky, Kenneth Robzyk, Edaise Da Silva, Paula J Torres, Brian R Untch, Janet Li, Promita Bose, Timothy A Chan, David S Klimstra, C David Allis, Laura H Tang
ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup. Nature communications 9 (1) (2018)
Diego Chowell, Luc G T Morris, Claud M Grigg, Jeffrey K Weber, Robert M Samstein, Vladimir Makarov, Fengshen Kuo, Sviatoslav M Kendall, David Requena, Nadeem Riaz, Benjamin Greenbaum, James Carroll, Edward Garon, David M Hyman, Ahmet Zehir, David B Solit, Michael F Berger, Ruhong Zhou, Naiyer A Rizvi, Timothy A Chan
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Science (New York, N.Y.) 359 (6375) (2017)
Sevin Turcan, Vladimir Makarov, Julian Taranda, Yuxiang Wang, Armida W M Fabius, Wei Wu, Yupeng Zheng, Nour El-Amine, Sara Haddock, Gouri J Nanjangud, H Carl LeKaye, Cameron Brennan, Justin Cross, Jason T Huse, Michael P Snyder, Pavel Osten, Craig B Thompson, Timothy A Chan
Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence. Nature genetics 50 (1) (2017)

Timothy A Chan.css-eqlu8i{font-size:small;padding-left:4px;} (Timothy Chan)

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Timothy A Chan (Timothy Chan)