Targeted Quantitative Plasma Metabolomics Identifies Metabolite Signatures that Distinguish Heart Failure with Reduced and Preserved Ejection Fraction.
Fawaz NaeemTeresa C LeoneChristopher PetucciClarissa ShofflerRavindra C KodihalliTiffany HidalgoCheryl Tow-KeoghJessica MancusoIphigenia TzameliDonald BennettJohn D GroarkeRachel J Roth FlachDaniel James RaderDaniel P KellyPublished in: medRxiv : the preprint server for health sciences (2024)
The plasma metabolomic changes seen in the heart failure cohorts support the existing theory of metabolic reprogramming, providing further rationale for the pursuit of therapeutic targets for the treatment of heart failure.Quantitative metabolomic profiling shows promise for guiding therapeutic decisions in HFrEF and HFpEF.Modulation of natriuretic peptides may enhance the delivery of ketone and fatty acids to the "fuel starved" failing heart.
Keyphrases
- heart failure
- ejection fraction
- aortic stenosis
- left ventricular
- fatty acid
- atrial fibrillation
- cardiac resynchronization therapy
- genome wide
- high resolution
- acute heart failure
- mass spectrometry
- clinical trial
- single cell
- cancer therapy
- coronary artery disease
- drug delivery
- dna methylation
- machine learning
- deep learning
- gene expression
- transcatheter aortic valve replacement
- replacement therapy
- smoking cessation