Defective FGFR1 Signaling Disrupts Glucose Regulation: Evidence From Humans With FGFR1 Mutations.
Maria I StamouCrystal J ChiuShreya V JadhavVanessa Ferreira LopesKathryn B SalnikovLacey PlummerMargaret F LippincottHang LeeStephanie B SeminaraRavikumar BalasubramanianPublished in: Journal of the Endocrine Society (2024)
These findings suggest that impaired FGFR1 signaling may contribute to an early insulin resistance phase of diabetes pathogenesis and support the candidacy of the FGFR1 signaling pathway as a therapeutic target for improving the human metabolic health.
Keyphrases
- insulin resistance
- signaling pathway
- type diabetes
- endothelial cells
- healthcare
- cardiovascular disease
- public health
- adipose tissue
- mental health
- epithelial mesenchymal transition
- high fat diet
- glycemic control
- induced pluripotent stem cells
- risk assessment
- polycystic ovary syndrome
- health information
- cell proliferation
- blood pressure
- climate change
- social media
- pluripotent stem cells