Exposure of Escherichia coli to antibiotic-efflux pump inhibitor combinations in a pharmacokinetic model: impact on bacterial clearance and drug resistance.
Alasdair P MacGowanM L G AttwoodAlan R NoelRoss W BarberZachary AronTimothy J OppermanElizabeth GrimseyJack StoneVito RicciLaura J V PiddockPublished in: The Journal of antimicrobial chemotherapy (2023)
AUC was the pharmacodynamic driver for chlorpromazine and PAβN while T > threshold was the driver for MBX-4191 and important in the activity of chlorpromazine and PAβN. Changes in population profiles did not occur with combinations of ciprofloxacin + EPIs, however, mutations in gyrA, gyrB and marR were detected.