Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.
Enrique Navas-PérezCristina Vicente-GarcíaSerena MirraDemian BurgueraNoèlia Fernàndez-CastilloJosé Luis FerránMacarena López-MayorgaMarta Alaiz-NoyaIrene Suárez-PereiraEster Antón-GalindoFausto UlloaCarlos Herrera-ÚbedaPol CuscóRafael Falcón-MoyaAntonio Rodríguez-MorenoSalvatore D'AnielloBru CormandGemma MarfanyEduardo SorianoÁngel M CarriónJaime J CarvajalJordi Garcia-FernàndezPublished in: Genome biology (2020)
We provide an in-depth understanding of the emergence of a gene cluster that originated by transposon domestication and gene duplication at the origin of placental mammals, an evolutionary process that transformed a non-functional transposon sequence into novel components of the eutherian genome. These genes were integrated into existing signaling pathways involved in the development, maintenance, and function of the CNS in eutherians. At least one of its members, Bex3, is relevant for higher brain functions in placental mammals and may be involved in human neurological disorders.
Keyphrases
- genome wide
- genome wide identification
- dna methylation
- copy number
- endothelial cells
- signaling pathway
- cerebral ischemia
- gene expression
- blood brain barrier
- transcription factor
- cell proliferation
- epithelial mesenchymal transition
- resting state
- optical coherence tomography
- oxidative stress
- subarachnoid hemorrhage
- pi k akt
- brain injury
- induced apoptosis
- pluripotent stem cells