Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis.

Ara Unanyan Laura Pivazyan Ekaterina Krylova Andrey Eskin Araksya Zakaryan Antonina Sarkisova Anatoly Ishchenko

Published in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2022)

To our knowledge, it is the first meta-analysis that estimates inositol treatment compared to metformin. Based on our systematic review and meta-analysis, metformin seems to be a good option for improving ART outcomes in women with PCOS. However, it is not clear whether inositol usage is adequate. Nevertheless, we need more clinical trials of good quality to answer all questions thoroughly.

Keyphrases

systematic review
clinical trial
polycystic ovary syndrome
randomized controlled trial
healthcare
hiv infected
quality improvement
antiretroviral therapy
type diabetes
insulin resistance
study protocol
case control
smoking cessation