Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis.
Miriam S UdlerJaegil KimMarcin von GrotthussSílvia Bonàs-GuarchJoanne B ColeJoshua ChiouChristopher D AndersonMichael BoehnkeMarkku LaaksoGil AtzmonBenjamin GlaserJosep Maria MercaderKyle GaultonJason FlannickGad GetzJose C FlorezPublished in: PLoS medicine (2018)
Our approach identifies salient T2D genetically anchored and physiologically informed pathways, and supports the use of genetics to deconstruct T2D heterogeneity. Classification of patients by these genetic pathways may offer a step toward genetically informed T2D patient management.