Triiodothyronine secretion in early thyroid failure: The adaptive response of central feedforward control.

Rudolf Hoermann Mark J PekkerJohn E M MidgleyRolf LarischJohannes Wolfgang Christian Dietrich

Published in: European journal of clinical investigation (2020)

Dependencies revealed in the expression of control differ in thyroid health and disease, using a physiologically based mathematical model of combined feedback-feedforward control of the hypothalamic-pituitary-thyroid regulation. Strong T3-protective mechanisms of the control system emerge with declining thyroid function, when glandular T3 secretion becomes increasingly influential over conversion efficiency. This has wide-ranging implications for the utility of TSH in clinical decision-making.

Keyphrases

decision making
healthcare
public health
poor prognosis
mental health
climate change
risk assessment