The overexpression of GDNF in nucleus accumbens suppresses alcohol-seeking behavior in group-housed C57Bl/6J female mice.

Maryna KoskelaT Petteri PiepponenMaria LindahlBrandon K HarveyJaan-Olle AndressooVootele VõikarMikko Airavaara

Published in: Journal of biomedical science (2021)

The effect of increased endogenous Gdnf mRNA level in female mice upon alcohol drinking has remained unknown. Our data suggest that an increase in endogenous GDNF expression upon alcohol drinking occurs in response to the activation of another mesolimbic reward pathway participant.

Keyphrases

alcohol consumption
high fat diet induced
poor prognosis
mental health
cell proliferation
signaling pathway
binding protein
electronic health record
transcription factor
type diabetes
big data
skeletal muscle
machine learning
insulin resistance