Monocytes - A Promising New TRAIL in Ovarian Cancer Cell Therapy.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Adoptive cell transfer of interferon (IFN)-activated monocytes administered intraperitoneally to patients with platinum-resistant ovarian cancer demonstrated anti-tumor effects and acceptable tolerability. The exposure of monocytes to IFNα and IFNγ upregulated TRAIL, which triggered caspase 8 and direct cell-to-cell contact-dependent apoptosis of ovarian cancer cells.

Keyphrases

cell therapy
dendritic cells
single cell
stem cells
immune response
mesenchymal stem cells
cell death
oxidative stress
randomized controlled trial
clinical trial
open label
cell proliferation
induced apoptosis
signaling pathway
study protocol