The SETD8/ELK1/bach1 complex regulates hyperglycaemia-mediated EndMT in diabetic nephropathy.

Xue LiLihong LuWenting HouFei WangTing HuangZhipeng MengMinmin Zhu

Published in: Journal of translational medicine (2022)

SETD8 cooperates with ELK1 to regulate bach1 transcription, thus participating in the progression of DN. In addition, SETD8 interacts with bach1 to modulate Snail transcription, thus inducing EndMT in DN. SETD8 plays a core role in the SETD8/ELK1/bach1 functional axis, which participates in hyperglycaemia-mediated EndMT in DN, and SETD8 may be a potential therapeutic target for DN. Trial registration ChiCTR, ChiCTR2000029425. 2020/1/31, http://www.chictr.org.cn/showproj.aspx?proj=48548.

Keyphrases

diabetic nephropathy
transcription factor
clinical trial
epithelial mesenchymal transition
study protocol
randomized controlled trial
phase iii
phase ii
human health