Early disease intervention with guselkumab in psoriasis leads to a higher rate of stable complete skin clearance ('clinical super response'): Week 28 results from the ongoing phase IIIb randomized, double-blind, parallel-group, GUIDE study.
Knut SchäkelKristian ReichK AsadullahAndreas PinterDenis JullienP WeisenseelC PaulM GomezS WegnerY PersonkeF KreimendahlYanqing ChenJ AngsanaM W L LeungK EyerichPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)
Guselkumab efficacy was consistent across subpopulations, on the skin and systemically. The proportion of SRes was higher in SDD than LDD patients, indicating early treatment intervention may improve clinical outcomes.