Dopamine/BDNF loss underscores narcosis cognitive impairment in divers: a proof of concept in a dry condition.
Gerardo BoscoTommaso Antonio GiaconNazareno PaolocciAlessandra VezzoliCinzia Della NoceMatteo PaganiniJacopo AgrimiGiacomo GarettoDanilo CialoniNatalie D'AlessandroEnrico M CamporesiMrakic-Sposta SimonaPublished in: European journal of applied physiology (2022)
Divers encounter IGN at - 48 msw, exhibiting a marked loss in circulating dopamine levels, likely accounting for BDNF-dependent impairment of mental capacity and heightened OxS. The decline in dopamine and BDNF appears to persist at decompression; thus, boosting dopamine/BDNF signaling via pharmacological or other intervention types might attenuate IGN in deep dives.