Angiotensin II receptor blockade alleviates calcineurin inhibitor nephrotoxicity by restoring cyclooxygenase 2 expression in kidney cortex.

Junda HuYan XuSebastian BachmannKerim Mutig

Published in: Acta physiologica (Oxford, England) (2021)

Suppression of juxtaglomerular COX-2 upon CsA results from RAS activation, which overrides the cell-autonomous, COX-2-stimulatory effects of calcineurin inhibition. Angiotensin II antagonism alleviates CsA nephrotoxicity via the COX-2-dependent normalization of creatinine clearance and sodium excretion.

Keyphrases

angiotensin ii
angiotensin converting enzyme
vascular smooth muscle cells
poor prognosis
single cell
mouse model
drug induced
binding protein
cell therapy
functional connectivity
uric acid
nitric oxide
bone marrow