Biomarker analyses investigating disease biology and associations with outcomes in the JAVELIN Merkel 200 trial of avelumab in metastatic Merkel cell carcinoma.

Sandra P D' Angelo Celeste Lebbè Paul T Nghiem Andrew S Brohl Thomas Mrowiec Trent Leslie Sara Georges Güelseren Güezel Parantu Shah

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Exploratory analyses provide insights into mMCC biology and potential associations with response to avelumab. Chemotherapy seems to negatively modulate the immune microenvironment.

Keyphrases

squamous cell carcinoma
stem cells
small cell lung cancer
clinical trial
study protocol
phase iii
locally advanced
randomized controlled trial
type diabetes
radiation therapy
risk assessment
climate change
glycemic control
insulin resistance