Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis.
Chia-Jui YenShu-Ting YangRuo-Yu ChenWenya HuangKazuaki ChayamaMing-Hao LeeShiang-Jie YangHong-Sheng LaiHsin-Yi YenYu-Wei HsiaoJu-Ming WangYih-Jyh LinLiang-Yi HungPublished in: Journal of biomedical science (2019)
The interaction between CPAP and HBx can provide a microenvironment to facilitate HCC development via enhancing NF-κB activation, inflammatory cytokine production, and cancer malignancies. This study not only sheds light on the role of CPAP in HBV-associated HCC, but also provides CPAP as a potential target for blocking the hyper-activated NF-κB in HCC.
Keyphrases
- hepatitis b virus
- obstructive sleep apnea
- positive airway pressure
- sleep apnea
- signaling pathway
- liver failure
- oxidative stress
- lps induced
- pi k akt
- papillary thyroid
- poor prognosis
- stem cells
- nuclear factor
- binding protein
- inflammatory response
- young adults
- cell proliferation
- human health
- climate change
- amino acid
- protein protein