Rho-kinase expression in Hirschsprung's disease.

David CoyleAnne Marie O'DonnellNicolae CorcionivoschiJohn GillickPrem Puri

Published in: Pediatric surgery international (2015)

This is the first report of strong ROCK expression in colonic ICCs. Although the rat model of aganglionic bowel suggests that Ca(2+)-independent smooth muscle contraction involving ROCK is hyper-activated, our data indicate ROCK 1 expression is decreased in aganglionic bowel and ROCK 2 expression is unaltered in children with HSCR.

Keyphrases

poor prognosis
smooth muscle
binding protein
long non coding rna
young adults
protein kinase
electronic health record
deep learning
ulcerative colitis
data analysis