IRF2-mediated upregulation of lncRNA HHAS1 facilitates the osteogenic differentiation of bone marrow-derived mesenchymal stem cells by acting as a competing endogenous RNA.
Guiwen YePeng WangZhongyu XieJinteng LiGuan ZhengWenjie LiuQian CaoMing LiShuizhong CenZhaofeng LiWenhui YuYanfeng WuHuiyong ShenPublished in: Clinical and translational medicine (2022)
Our study identified a novel lncRNA, HHAS1, that facilitates BMSC osteogenic differentiation and proposed a role for the IRF2/HHAS1/miR-204-5p/RUNX2 axis in BMSC osteogenesis regulation. These findings help elucidate the regulatory network of BMSC osteogenesis and provide potential targets for clinical application.