Clinical improvement of DM1 patients reflected by reversal of disease-induced gene expression in blood.
Remco T P van CruchtenDaniël van AsJeffrey C GlennonBaziel G M van EngelenPeter A C 't Hoennull nullnull nullPublished in: BMC medicine (2022)
DM1-relevant disease signatures can be identified on a molecular level in peripheral blood, opening new avenues for drug discovery and therapy efficacy assessments.
Keyphrases
- drug discovery
- gene expression
- peripheral blood
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- dna methylation
- prognostic factors
- peritoneal dialysis
- high glucose
- genome wide
- drug induced
- oxidative stress
- single molecule
- patient reported outcomes
- skeletal muscle
- weight loss
- patient reported
- replacement therapy