Optical Imaging Demonstrates Tissue-Specific Metabolic Perturbations in Mblac1 Knockout Mice.

Busenur Ceyhan Parisa Nategh Mehrnoosh NeghabiJacob A LaMarShalaka Konjalwar Peter RodriguezMaureen K HahnMatthew GrossGregory GrumbarKenneth J SallengRandy D Blakely

Published in: IEEE journal of translational engineering in health and medicine (2024)

As seen with C. elegans swip-10 mutants, loss of MBLAC1 protein results in metabolic changes that are not restricted to neural cells and are consistent with the presence of peripheral comorbidities accompanying neurodegenerative disease in cases where MBLAC1 expression changes impact risk.

Keyphrases

high resolution
induced apoptosis
poor prognosis
cell cycle arrest
binding protein
high speed
oxidative stress
endoplasmic reticulum stress
mass spectrometry
signaling pathway
cell death
long non coding rna
fluorescence imaging
pi k akt