The Phospholipid Flippase ATP8B1 is Involved in the Pathogenesis of Ulcerative Colitis via Establishment of Intestinal Barrier Function.
Pim J KoelinkValentina E Gómez-MelladoSuzanne DuijstManon van RoestSander MeisnerKam S Ho-MokSabrina FrankBabette S AppelmanLysbeth Ten BloemendaalGeorg F VogelStan F J van de GraafPiter J BosmaRonald P J Oude ElferinkManon E WildenbergCoen C PaulusmaPublished in: Journal of Crohn's & colitis (2024)
ATP8B1 is important in the establishment of the intestinal barrier. Downregulation of ATP8B1 levels in UC, and subsequent altered localization of tight junctional proteins, including CLDN4, might therefore be an important mechanism in UC pathophysiology.