High levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) in the serum are associated with poor prognosis in HPV-negative squamous cell oropharyngeal cancer.
Timo CarpénTimo SorsaLauri JouhiTaina TervahartialaCaj HaglundStina M SyrjänenJussi TarkkanenHesham MohamedAntti Aarni MäkitieJaana HagstromPetri S MattilaPublished in: Cancer immunology, immunotherapy : CII (2019)
Our results indicate that serum TIMP-1 levels may serve as an independent prognostic marker for HPV-negative OPSCC patients.