Reduced protocadherin17 expression in leukemia stem cells: the clinical and biological effect in acute myeloid leukemia.

Zi-Jun XuJi-Chun MaJing-Dong ZhouXiang-Mei WenDong-Ming YaoWei ZhangRun-Bi JiDe-Hong WuLi-Juan TangZhao-Qun DengJun QianJiang Lin

Published in: Journal of translational medicine (2019)

PCDH17 gene was silenced by DNA methylation in AML. Low PCDH17 expression is associated with distinct clinical and biological features and improves risk stratification in patients with AML.

Keyphrases

acute myeloid leukemia
stem cells
poor prognosis
dna methylation
genome wide
gene expression
binding protein
allogeneic hematopoietic stem cell transplantation
bone marrow
transcription factor
mesenchymal stem cells