A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Antiapoptotic Protein in Kidney Cancer.
Treg GrubbSmruthi MagantiJohn Michael Krill-BurgerCameron S FraserLaura StranskyTomas RadivoyevitchKristopher A SarosiekFrancisca VazquezWilliam G KaelinAbhishek A ChakrabortyPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Our studies uncovered an unexpected link between cell state and BCL-XL dependence in ccRCC. Therapeutic agents that specifically target BCL-XL are available. Our work justifies testing the utility of BCL-XL blockade to target, likely, a clinically aggressive subset of human kidney cancers. See related commentary by Wang et al., p. 4600.