One of the greatest frequent types of malignancy is gastric cancer (GC). Metastasis, an essential feature of stomach cancer, results in a high rate of mortality and a poor prognosis. However, metastasis biological procedures are not well recognized. Long non-coding RNAs (lncRNAs) have a role in numerous gene regulation pathways via epigenetic modification as well as transcriptional and post-transcriptional control. LncRNAs have a role in a variety of disorders, such as cardiovascular disease, Alzheimer's, and cancer. LncRNAs are substantially related to GC incidence, progression, metastasis and drug resistance. Several research released information on the molecular processes of lncRNAs in GC pathogenesis. By interacting with a gene's promoter or enhancer region to influence gene expression, lncRNAs can operate as an oncogene or a tumor suppressor. This review includes the lncRNAs associated with metastasis of GC, which may give insights into the processes as well as potential clues for GC predicting and tracking.
Keyphrases
- long non coding rna
- poor prognosis
- gene expression
- genome wide identification
- genome wide analysis
- transcription factor
- network analysis
- cardiovascular disease
- dna methylation
- gas chromatography
- papillary thyroid
- type diabetes
- risk factors
- cardiovascular events
- genome wide
- mass spectrometry
- machine learning
- deep learning
- climate change
- squamous cell carcinoma
- single molecule
- metabolic syndrome
- high resolution
- cardiovascular risk factors
- copy number
- liquid chromatography