Fast design of arbitrary length loops in proteins using InteractiveRosetta.

William F HooperBenjamin D WalcottXing WangChristopher Bystroff

Published in: BMC bioinformatics (2018)

INDEL was able to find viable loops in 100% of 500 attempts for all lengths from 3 to 20 residues. INDEL has been applied to the task of designing a domain-swapping loop for T7-endonuclease I, changing its specificity from Holliday junctions to paranemic crossover (PX) DNA.

Keyphrases

single molecule
circulating tumor
cell free
dna repair
open label
transcription factor
double blind
placebo controlled
randomized controlled trial
clinical trial
dna damage