Have (R)-[11C]PK11195 challengers fulfilled the promise? A scoping review of clinical TSPO PET studies.
Fabien ChauveauGuillaume BeckerHerve BoutinPublished in: European journal of nuclear medicine and molecular imaging (2021)
Generally, challengers confirmed disease-specific initial (R)-[11C]PK11195 findings. However, while their better signal-to-noise ratio seems particularly useful in diseases with moderate and widespread neuroinflammation, most challengers present an allelic-dependent (Ala147Thr polymorphism) TSPO binding and genetic stratification is hindering their clinical implementation. As new challengers, insensitive to TSPO human polymorphism, are about to enter clinical evaluation, we propose this systematic review to be regularly updated (living review).
Keyphrases
- pet imaging
- systematic review
- clinical evaluation
- endothelial cells
- primary care
- traumatic brain injury
- meta analyses
- air pollution
- genome wide
- gene expression
- machine learning
- dna methylation
- pet ct
- cognitive impairment
- lps induced
- induced pluripotent stem cells
- inflammatory response
- copy number
- dna binding
- binding protein
- pluripotent stem cells
- subarachnoid hemorrhage