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N 6 -methylation in the development, diagnosis, and treatment of gastric cancer.

Jiaxin WangGuiping ZhaoYan ZhaoZheng ZhaoShuyue YangAnni ZhouPeng LiShutian Zhang
Published in: Journal of translational internal medicine (2024)
Gastric cancer (GC) ranks third among cancers in terms of mortality rate worldwide. A clear understanding of the mechanisms underlying the genesis and progression of GC will contribute to clinical decision making. N 6 -methyladenosine (m 6 A) is the most abundant among diverse mRNA modification types and regulates multiple facets of RNA metabolism. In recent years, emerging studies have shown that m 6 A modifications are involved in gastric carcinoma tumorigenesis and progression and can potentially be valuable new prospects for diagnosis and prognosis. This article reviews the recent progress regarding m 6 A in GC.
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