HGF potentiates extracellular matrix-driven migration of human myoblasts: involvement of matrix metalloproteinases and MAPK/ERK pathway.

Mariela Natacha GonzálezWallace de MelloGillian S Butler-BrowneSuse Dayse Silva-BarbosaVincent MoulyWilson SavinoIngo Riederer

Published in: Skeletal muscle (2017)

We demonstrate that HGF induces ERK phosphorylation and MMP production, thus stimulating human myoblast migration on ECM molecules. Conceptually, these data state that the mechanisms involved in the migration of human myoblasts comprise both soluble and insoluble moieties. This should be taken into account to optimize the design of therapeutic cell transplantation strategies by improving the migration of donor cells within the host tissue, a main issue regarding this approach.

Keyphrases

extracellular matrix
endothelial cells
signaling pathway
induced pluripotent stem cells
pi k akt
cell proliferation
pluripotent stem cells
induced apoptosis
oxidative stress
machine learning
big data
cell cycle arrest
deep learning
artificial intelligence
bone marrow
endoplasmic reticulum stress
protein kinase