SETD8 cooperates with MZF1 to participate in hyperglycemia-induced endothelial inflammation via elevation of WNT5A levels in diabetic nephropathy.
Fei WangWenting HouXue LiLihong LuTing HuangMinmin ZhuChanghong MiaoPublished in: Cellular & molecular biology letters (2022)
MZF1 links with SETD8 to regulate WNT5A expression in HGECs, thus elevating levels of hyperglycemia-mediated inflammatory factors in glomerular endothelium of DN patients and rats. Trial registration ChiCTR, ChiCTR2000029425. 2020/1/31, http://www.chictr.org.cn/showproj.aspx?proj=48548.
Keyphrases
- diabetic nephropathy
- diabetic rats
- oxidative stress
- end stage renal disease
- high glucose
- stem cells
- cell proliferation
- newly diagnosed
- poor prognosis
- endothelial cells
- chronic kidney disease
- clinical trial
- nitric oxide
- prognostic factors
- study protocol
- peritoneal dialysis
- phase iii
- squamous cell carcinoma
- patient reported outcomes
- drug induced
- patient reported