Iron supplementation and the risk of bronchopulmonary dysplasia in extremely low gestational age newborns.
Melissa R GarciaBryan A ComstockRavi M PatelVeeral N ToliaCassandra D JosephsonMichael K GeorgieffRaghavendra RaoSarah E MonsellSandra E JuulKaashif Aqeeb Ahmadnull nullPublished in: Pediatric research (2022)
NCT01378273. https://clinicaltrials.gov/ct2/show/NCT01378273 IMPACT: Prior studies and biologic plausibility raise the possibility that iron administration could contribute to the pathophysiology of oxidant-induced lung injury and thus bronchopulmonary dysplasia in preterm infants. For 24-27-week premature infants, this study finds no association between total cumulative enteral iron supplementation at either 28-day or 36-week postmenstrual age and the risk for developing bronchopulmonary dysplasia.
Keyphrases
- gestational age
- preterm infants
- birth weight
- preterm birth
- low birth weight
- iron deficiency
- rheumatoid arthritis
- computed tomography
- high glucose
- pregnant women
- image quality
- diabetic rats
- clinical trial
- randomized controlled trial
- placebo controlled
- positron emission tomography
- oxidative stress
- endothelial cells
- anti inflammatory
- pet ct