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Analyzing intent-to-treat and per-protocol effects on safety outcomes using a medical information database: an application to the risk assessment of antibiotic-induced liver injury.

Yoshinori TakeuchiTomohiro ShinozakiHiraku KumamaruTatsuo HiramatsuYutaka Matsuyama
Published in: Expert opinion on drug safety (2018)
Researchers should clearly define the target estimands, and carefully estimate and interpret both effects.
Keyphrases
  • risk assessment
  • healthcare
  • randomized controlled trial
  • heavy metals
  • health information
  • emergency department
  • type diabetes
  • social media