Omega-3 Fatty Acids and Genome-Wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.
Jiayi XuNathan C GaddisTraci M BartzRuixue HouAni W ManichaikulNathan PankratzAlbert Vernon SmithFangui SunNatalie TerzikhanChristina A MarkunasBonnie K PatchenMatthew SchuMay A BeydounGuy G BrusselleGudny EiriksdottirXia ZhouAlexis C WoodMariaelisa GraffTamara B HarrisM Arfan IkramDavid R JacobsLenore J LaunerRozenn N LemaitreGeorge T O'ConnorElizabeth C OelsnerBruce M PsatyRamachandran S VasanRebecca R RohdeStephen S RichJerome I RotterSudha SeshadriLewis J SmithHenning TiemeierMichael Y TsaiAndré G UitterlindenV Saroja VorugantiHanfei XuNuno R ZilhãoMyriam FornageM Carola ZillikensStephanie J LondonR Graham BarrJosée DupuisSina A GharibVilmundur GudnasonLies LahousseKari E NorthLyn M SteffenPatricia A CassanoDana B HancockPublished in: American journal of respiratory and critical care medicine (2020)
We corroborated beneficial effects of n-3 PUFAs on pulmonary function. By modeling genome-wide n-3 PUFA interactions, we identified a novel DPP10 SNP association with FVC that was not detectable in much larger studies ignoring this interaction.