Outcomes of Hepatic Artery-Based Therapies and Systemic Multiagent Chemotherapy in Unresectable Colorectal Liver Metastases: A Systematic Review and Meta-analysis.

Kavin SugumarHenry StitzelVictoria WuDavid BajorSakti ChakrabartiMadison ConcesLauren HenkeMelissa LumishAmit MahipalAmr MohamedJordan M WinterJeffrey M HardacreJohn B AmmoriJennifer E SelfridgeLee M Ocuin

Published in: Annals of surgical oncology (2024)

HAI-S and multiagent chemotherapy are effective therapies for UCRLM. To make definitive conclusions, a randomized trial with comparable patient characteristics and line of therapy will be required. The upcoming EA2222 PUMP trial may help to address this question.

Keyphrases

liver metastases
locally advanced
rectal cancer
squamous cell carcinoma
radiation therapy
clinical trial
study protocol
phase iii
case report
phase ii
randomized controlled trial
chemotherapy induced
open label
double blind
placebo controlled