Long Noncoding RNA LEMD1-AS1 Increases LEMD1 Expression and Activates PI3K-AKT Pathway to Promote Metastasis in Oral Squamous Cell Carcinoma.

Zaiye LiJie WangJianjun WuNing LiCanhua Jiang

Published in: BioMed research international (2022)

We established the lncRNA-mRNA landscape of metastatic OSCC, which indicated that LEMD1-AS1 enhanced OSCC metastasis by stabilizing its antisense transcript LEMD1. Thus, LEMD1-AS1 is a potential biomarker for predicting metastasis, as well as a therapeutic target of OSCC.

Keyphrases

long noncoding rna
poor prognosis
squamous cell carcinoma
small cell lung cancer
binding protein
long non coding rna
single cell
rna seq