Host E3 ubiquitin ligase ITCH mediates Toxoplasma gondii effector GRA35-triggered NLRP1 inflammasome activation and cell-autonomous immunity.

Yifan WangL Robert HollingsworthLamba Omar SangaréTatiana C Paredes-SantosShruthi KrishnamurthyBennett H PennHao WuJeroen P J Saeij

Published in: bioRxiv : the preprint server for biology (2023)

in human fibroblasts stimulated by IFNγ. Thus, this research provides valuable insights into understanding pathogen recognition and restriction mediated by host E3 ubiquitin ligase.

Keyphrases

toxoplasma gondii
nlrp inflammasome
dendritic cells
endothelial cells
single cell
immune response
cell therapy
induced pluripotent stem cells
regulatory t cells
pluripotent stem cells
stem cells
extracellular matrix
mesenchymal stem cells