LRP1 mediates leptin transport by coupling with the short-form leptin receptor in the choroid plexus.
Aaron Aykut UnerWon-Mo YangMin-Cheol KangKellen Cristina da Cruz RodriguesAhmet AydoganJi A SeoNatalia F MendesMin-Seon KimFatima Ezzahra TimzouraMichael J HoltzmanMaria LehtinenVincent PrevotYoung-Bum KimPublished in: bioRxiv : the preprint server for biology (2023)
Adipocyte-derived leptin enters the brain to exert its anorexigenic action, yet its transport mechanism is poorly understood. Here we report that LRP1 (low-density lipoprotein receptor-related protein-1) mediates the transport of leptin across the blood-CSF barrier in Foxj1 expressing cells highly enriched at the choroid plexus (ChP), coupled with the short-form leptin receptor, and LRP1 deletion from ependymocytes and ChP cells leads to leptin resistance and hyperphagia, causing obesity. Thus, LRP1 in epithelial cells is a principal regulator of leptin transport in the brain.
Keyphrases
- low density lipoprotein
- induced apoptosis
- type diabetes
- metabolic syndrome
- white matter
- resting state
- weight loss
- adipose tissue
- oxidative stress
- transcription factor
- endoplasmic reticulum stress
- binding protein
- ultrasound guided
- physical activity
- skeletal muscle
- signaling pathway
- fatty acid
- brain injury
- weight gain
- ionic liquid
- pi k akt