Impaired immunoregulatory network of the CD4 T lymphocytes in refractory asthma.

Jamille S FernandesMaria Ilma AraujoTarcísio V V S de AlmeidaLorena S AndradeDiego M LopesLuane M de MelloEdgar M CarvalhoÁlvaro A CruzLuciana Santos Cardoso

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)

Our data suggest that refractoriness to treatment in asthma is associated with a lower expression of distinct regulatory molecules by CD4 T cells between those who are atopic and have EOA and those who are non-atopic and have LOA. Thus, these results may contribute to the identification of new regulatory strategies to treat asthma according to their phenotypes.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
transcription factor
poor prognosis
electronic health record
atopic dermatitis
cystic fibrosis
air pollution
binding protein
machine learning
combination therapy
bioinformatics analysis