Impaired immunoregulatory network of the CD4 T lymphocytes in refractory asthma.
Jamille S FernandesMaria Ilma AraujoTarcísio V V S de AlmeidaLorena S AndradeDiego M LopesLuane M de MelloEdgar M CarvalhoÁlvaro A CruzLuciana Santos CardosoPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2019)
Our data suggest that refractoriness to treatment in asthma is associated with a lower expression of distinct regulatory molecules by CD4 T cells between those who are atopic and have EOA and those who are non-atopic and have LOA. Thus, these results may contribute to the identification of new regulatory strategies to treat asthma according to their phenotypes.