Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.
Chang-Suk ChaeTito A SandovalSung-Min HwangEun Sil ParkPaolo GiovanelliDeepika AwasthiCamilla SalvagnoAlexander EmmanuelliChen TanVidyanath ChaudharyJulia CasadoAndrew V KossenkovMinkyung SongFranck J BarratKevin HolcombE Alfonso Romero-SandovalDmitriy ZamarinDavid PépinAlan D' AndreaAnniina FarkkilaJuan R Cubillos-RuizPublished in: Cancer discovery (2022)
This study uncovers that ATX-LPA is a central immunosuppressive pathway in the ovarian tumor microenvironment. Ablating this axis sensitizes ovarian cancer hosts to various immunotherapies by unleashing protective type I IFN responses. Understanding the immunoregulatory programs induced by LPA could lead to new biomarkers predicting resistance to immunotherapy in patients with cancer. See related commentary by Conejo-Garcia and Curiel, p. 1841. This article is highlighted in the In This Issue feature, p. 1825.