The impact of APOE ε4 in Alzheimer's disease: a meta-analysis of voxel-based morphometry studies.
Madison BaileyZlatomira Georgieva IlchovskaAkram A HosseiniJe Young JungPublished in: medRxiv : the preprint server for health sciences (2024)
Our meta-analysis sheds light on the significant link between the APOE ε4 allele and hippocampal atrophy in both AD and MCI, emphasizing the allele's critical influence on neurodegeneration, especially in the hippocampus. Our findings contribute to the understanding of the disease's pathology, potentially facilitating progress in early detection, targeted interventions, and personalized care strategies for individuals with the APOE ε4 allele who are at risk for Alzheimer's Disease.
Keyphrases
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- randomized controlled trial
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- cerebral ischemia
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- affordable care act