Intestinal chemosensitivity in irritable bowel syndrome associates with small intestinal TRPV channel expression.

Madhusudan GroverAntonio BerumenStephanie PetersTing WeiMargaret Breen-LylesWilliam S HarmsenIrene BusciglioDuane BurtonMaria Vazquez RoqueKenneth R DeVaultMichael CamilleriMichael WallaceSurendra DasariHelmut NeumannLesley A Houghton

Published in: Alimentary pharmacology & therapeutics (2021)

Lipid infusion elicits a greater symptom response in IBS patients than HV, which is associated with small intestinal expression of TRPV channels. TRPV-mediated small intestinal chemosensitivity may mediate post-meal symptoms in IBS.

Keyphrases

irritable bowel syndrome
poor prognosis
end stage renal disease
neuropathic pain
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
low dose
binding protein
prognostic factors
patient reported
physical activity