Alzheimer's disease marker phospho-tau181 is not elevated in the first year after moderate-to-severe TBI.

Neil Samuel Nyholm GrahamKarl ZimmermanAmanda J HeslegraveAshvini KeshavanFederico MoroSamia Abed-MaillardAdriano BerniniVincent DunetElena GarberoGiovanni NattinoArturo ChieregatoEnrico FainardiCamelia BaciuPrimoz GradisekSandra MagnoniMauro OddoGuido BertoliniJonathan M Schott Henrik Zetterberg David James Sharp

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

Plasma p-tau181 is not significantly elevated during the first year after moderate-to-severe TBI and levels do not relate to neuroimaging measures of neurodegeneration.

Keyphrases

traumatic brain injury
high intensity
early onset
cerebrospinal fluid
severe traumatic brain injury
mild traumatic brain injury
cognitive decline
mild cognitive impairment