MicroRNAs miR-7 and miR-340 predict response to neoadjuvant chemotherapy in breast cancer.
Mithu RaychaudhuriHolger BrongerTheresa BuchnerMarion KiechleWilko WeichertStefanie AvrilPublished in: Breast cancer research and treatment (2017)
Intratumoral expression of miR-7 and miR-340 prior to neoadjuvant chemotherapy could be used to predict pCR and a profile of miR-7low or miR-340high identified patients unlikely to achieve pCR who might benefit from alternative treatment options including earlier surgery. Our study identifies miRNAs as promising predictive biomarkers, which could aid in optimization of breast cancer management and treatment stratification.
Keyphrases
- neoadjuvant chemotherapy
- cell proliferation
- long non coding rna
- long noncoding rna
- poor prognosis
- locally advanced
- lymph node
- sentinel lymph node
- end stage renal disease
- genome wide
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- radiation therapy
- gene expression
- dna methylation
- acute coronary syndrome
- binding protein
- young adults
- percutaneous coronary intervention