Cyasterone ameliorates sepsis-related acute lung injury via AKT (Ser473)/GSK3β (Ser9)/Nrf2 pathway.
Miao LinWeixi XieDayan XiongSiyuan TangXiaoting HuangLang DengLei HuangXiaohua ZhangTingting ZhouRui QianQian ZengXiaoxue SangYuyang LuoQingzhong HuaLu RenWei LiuPublished in: Chinese medicine (2023)
Cyasterone defends against sepsis-induced ALI by inhibiting inflammatory responses and oxidative stress, which depends heavily on the upregulation of the Nrf2 pathway through phosphorylation of AKT(Ser473)/GSK3β(Ser9). These results suggest cyasterone may be a valuable drug candidate for preventing sepsis-related ALI.
Keyphrases
- signaling pathway
- oxidative stress
- septic shock
- acute kidney injury
- diabetic rats
- intensive care unit
- pi k akt
- cell proliferation
- induced apoptosis
- drug induced
- lipopolysaccharide induced
- high glucose
- mouse model
- lps induced
- poor prognosis
- emergency department
- inflammatory response
- adverse drug
- long non coding rna
- endoplasmic reticulum stress
- heat shock protein