CD137 (4-1BB) and T-Lymphocyte Exhaustion.
Paula Molero-GlezArantza AzpilikuetaLaura MosteoJavier Glez-VazBelen PalenciaIgnacio Melero BermejoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
CD137 (4-1BB) costimulation results in the potent activation of antitumor T lymphocytes and elicits antitumor efficacy that is synergistic with anti-PD(L)1 checkpoint inhibitors, especially when using bispecific constructs. Emerging experimental evidence indicates that 4-1BB ligation prevents and may revert T-cell exhaustion. See related article by Jeon et al., p. XX.