Proteinopathy and Longitudinal Cognitive Decline in Parkinson Disease.
Peter S MyersJohn L O'DonnellJoshua J JacksonChristina N Lessov-SchlaggarRebecca L MillerErin R FosterCruchaga CarlosBruno A BenitezPaul T KotzbauerJoel S PerlmutterMeghan C CampbellPublished in: Neurology (2022)
Presence or risk of β-amyloid accumulation consistently predicted cognitive decline and time to dementia in PD. This suggests that β-amyloid has high potential as a prognostic indicator and biomarker for cognitive changes in PD.